Institut für Theoretische Physik
Start / Aktuell / Institut
Juli  2014
Seminarraum A3.101
Theoretische Physik
Theoretisch-physikalisches Seminar

Imke Schneider
University of Oxford

Threshold singularities in one-dimensional metals

The low-energy behaviour of generic critical one-dimensional quantum systems is usually described within the Luttinger liquid theory. It simplifies the real system by replacing the true energy-momentum relation for its particles by a linear one. Precisely because of band curvature effects Luttinger liquid theory - despite its remarkable success for thermodynamic properties - breaks down when we are interested in singularities in dynamical response functions. Recent developments using a mapping to a Luttinger liquid with an additional high frequency mobile impurity permit the description of effects due to the spectral nonlinearity. We give an introduction to the theory of nonlinear Luttinger liquids and present a constructive derivation of a mobile impurity model for spin-1/2 fermions.

SR 3, Institut für Theoretische Physik, A03.101
SFB 937

Prof. Motomu Tanaka
University of Heidelberg

What Shape and Motion Talk: Physics of Human Diseases

Diseases and development are highly complex, stochastic processes in nature. For example, the morphological dynamics of metastatic cancer cells during migration is highly stochastic. The combination of quantitative in vitro models, live cell imaging, and statistical physics gives us a powerful tool to experimentally unravel characteristic spatio-temporal information behind the stochastic noise, which is not accessible with phenomenological observation.

I will introduce two examples of how the combination of quantitative models of biological interfaces [1] and tools in statistical physics can be used to understand some principles in cancer. In the first example, we identified characteristic spatio-temporal patterns in metastatic/non-metastatic murine pancreatic cancer cells on model cell surfaces displaying hyaluronic acid oligomer, which is known as a key ligand in cancer metastasis [2]. It has been demonstrated that the quantitative analysis of physical readouts, such shape and mode of motion of cancer cells, can potentially be used as a novel clinico-pathological tool. In the latter half, I will extend this subject to our recent challenge to identify the impact of clinical drugs on the adhesion of hematopoietic stem cells vs. leukemia stem cells on bone marrow model surfaces [3]. [1] Tanaka, M. and E. Sackmann, Polymer-Supported Membranes as Models of the Cell Surface. Nature, 2005. 437: p. 656-663 [2] Kaindl, T., H. Rieger, L.-M. Kaschel, U. Engel, A. Schmaus, J. Sleeman, and M. Tanaka, Spatio-Temporal Patterns of Pancreatic Cancer Cells Expressing CD44 Isoforms on Supported Membranes Displaying Hyaluronic Acid Oligomers Arrays. PLoS ONE, 7, e42991 (2012). [3] Burk, A., C. Monzel, H. Yoshikawa, P. Wuchter, R. Saffrich, M. Tanaka, and A.D. Ho, Quantifying Adhesion Mechanisms and Dynamics of Human Hematopoietic Stem and Progenitor Cells on In Vitro Bone Marrow Niche Models, submitted.

Kontakt: Glormann

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